It was the first retinoid developed for this type of topical use. Tretinoin is the best studied retinoid in the treatment of photoaging.
It is used by some as a hair loss treatment and also a component of many commercial products that are advertised as being able to slow skin aging or remove wrinkles.
Topical tretinoin is also used to treat and reduce the appearance of stretch marks by increasing collagen production in the dermis.
It is a drug commonly used to treat acne vulgaris and keratosis pilaris.
It is available as a cream or gel (brand names Aberela, Airol, Renova, Atralin, Retin-A, Avita, or Stieva-A).
It is also used to treat acute promyelocytic leukemia (APL), and is sold for this indication by Roche under the brand name Vesanoid. It is also available as a generic.